江北抗日根据地食盐产销制度述论

抗战时期，江北抗日根据地各级政府在夺取两淮盐区后，通过在生产、销售、税收、缉私等方面采取的一系列措施，建立了行之有效的食盐产销制度。这使当地盐业在夯实抗战经济基础、改善民众生活等方面作出积极贡献，同时也为进一步的制度探索奠定了基础。     

A comparative study of adaptive trial designs for dose optimization

Recently, the US Food and Drug Administration Oncology Center of Excellence initiated Project Optimus to reform the dose optimization and dose selection paradigm in oncology drug development. The agency pointed out that the current paradigm for dose selection—based on the maximum tolerated dose (MTD)—is not sufficient for molecularly targeted therapies and immunotherapies, for which efficacy may not increase after the dose reaches a certain level. In these cases, it is more appropriate to identify the optimal biological dose (OBD) that optimizes the risk–benefit tradeoff of the drug. Project Optimus has spurred tremendous interest and urgent need for guidance on designing dose optimization trials. In this article, we review several representative dose optimization designs, including model-based and model-assisted designs, and compare their operating characteristics based on 10,000 randomly generated scenarios with various dose-toxicity and dose-efficacy curves and some fixed representative scenarios. The results show that, compared with model-based designs, model-assisted methods have advantages of easy-to-implement, robustness, and high accuracy to identify OBD. Some guidance is provided to help biostatisticians and clinicians to choose appropriate dose optimization methods in practice.     

全面抗战初期新加坡侨报视野中的新四军——以《总汇新报》相关新闻报道为中心(1938—1939)

全面抗战初期，以《总汇新报》为代表的新加坡华媒刊发了大量有关新四军的新闻报道，既有对战略战术、光辉战绩、革命精神等方面的宏观分析，又不乏在微观视角下对新四军日常训练、战斗经过、军民关系等方面的观察记录，呈现出一个坚决抗日、政治过硬的先锋劲旅，战术高明、训练有素的威武之师以及作风优良、军民团结的爱国军队形象，从而引发南洋侨界的情感共鸣与广泛支持，同时也见证了中国共产党在抗日战争中的中流砥柱作用。     

区域战略性新兴产业的分阶段选择模型及应用——以重庆市为例

运用定量评价与定性分析相结合的研究方法，构建了区域战略性新兴产业的分阶段选择模型。模型将选择过程细分为区域分析、定量选择和综合分析三个阶段，解决目前战略性新兴产业分类与现有统计数据分类存在差异、选择过程复杂等问题。以重庆市为例进行实证分析：第一阶段通过对重庆市进行区位分析筛选出有色金属采选业、金融等35个产业；第二阶段针对第二产业和第三产业分别采用因子分析法和熵值法进行优选，得到交通运输设备制造业、金融等13个产业；第三阶段结合技术发展方向对以上产业进一步分析，提出重庆市战略新兴产业重点应放在高端装备制造业和新一代信息技术，其次是新能源汽车、生物医药和新能源领域。